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KMID : 0978920130140010027
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Korean Journal of Clinical Geriatrics
2013 Volume.14 No. 1 p.27 ~ p.31
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Can Catechol-O-methyltransferase Inhibitor Prevent Polyneuropathy in Parkinson’s Disease?
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Jeong Hye-Young
Song In-Uk
Chung Sung-Woo
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Abstract
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Background: Polyneuropathy has recently been described in higher proportions for Parkinson’s disease. The homocysteine (hcy) levels in PD treated with levodopa are thought to be elevated by increased synthesis from the metabolism of levodopa by COMT. It was thought that COMT-inhibitor (COMT-I) may reduce elevated hcy levels. We conducted this study to clarify that COMT-I on patients with PD is able to prevent occurrence of polyneuropathy in PD.
Methods: 37-PD without neuropathy (PDWo) and 41-PD with polyneuropathy (PDP) were compared with 48 healthy controls. All PD patients performed electrophysiological tests. Plasma hcy levels were measured in all subjects and compared with each groups. And we evaluated to relate with hcy level and polyneuropathy in two groups of PD (levodopa-alone treated group and levodopa plus COMT-inhibitor treated group).
Results: The hcy levels of PDP showed higher than those of PDWo as well as healthy controls. In regarding to effect of COMT-I, no correlation was found hcy levels in two subgroups in PD. There was no significant effect of COMT-I
on occurrence of polyneuropathy in PD.
Conclusion: Our findings agree with previous studies indicating that levodopa treatment in PD patients results in elevated hcy concentrations, whereas COMT-I show no preventive effect on involvement of peripheral nerve system in PD patients.
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KEYWORD
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Parkinson’s disease, Polyneuropathy, COMT-inhibitor, Homocysteine
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